Huge lag spike renders game unplayable

After exploring a very large section of the map and creating around 77,000 chunks, if I move back to pre-rendered chunks a short distance away the framerate drops down to 0 FPS and will move one frame only every few seconds. Closing the window and reopenning fixes this problem, but it will persist continuously after moving a distance. This is very frustrating when you have distant mines and minecart systems.