Large red mushroom caps can break non-full blocks, including end portal frames, end gateways, barriers and shulker boxes

To replicate:

1. Place a Red Mushroom on a block of Podzol.
2. Place a Barrier Block, End Portal Frame, End Gateway, or Shulker Box in the area where a Large Mushroom's cap would generate.
3. Bonemeal the Red Mushroom.

Does not effect Bedrock Blocks.

Untested on other potentially game-breaking blocks aside from the above mentioned 5.